Until recently, there were no drugs to treat colds and flu, other than paracetamol for pain, rest and plenty of fluids.
Then drug companies began to make anti-viral medications aimed at actually stopping flu. Roche made Tamiflu and when it was released, the public eagerly bought it up, thinking their days of feverish misery were over. However, they quickly found out that instead of stopping the flu, Tamiflu was simply supposed to reduce the number of days you suffered from it.
So it turned out to be a flop. The public weren't interested. They wanted a quick fix, to take a pill and be magically well - the same senario they expect with vaccination. Just take some shots and never get diseases even if you eat junk food, fill yourself with pills, never exercise and don't drink water. It's okay because you've had your shots.
Because of this quick fix mentality, the drug didn't sell as well as Roche were hoping.
Then in 2005, the DOH predicted an avian flu pandemic in which they said millions could die and the British government bought up 20 MILLION doses of Tamiflu,in October of that year, at a cost of 2 BILLION pounds to 'be prepared' for this disasterous avian flu pandemic. Well, the avian flu pandemic never happened and the DOH were left with 20 million doses of Tamiflu that they didn't know what to do with.
Now they forecast a swine flu pandemic and guess what? Tamiflu just happens to be the magic treatment for swine flu.
Schools in the UK have been shut down over 1 case of the disease and Tamiflu is being given to students without parental consent, in spite of contraindications and without checking the children's medical histories. There have even been reports where parents have gone to their child's school, concerned, and found it under police guard and they have been unable to see their children who have been foricbly administered this medication.
The shelf life for Tamiflu happens to be 3 years, and right about now is when the 20 million doses the government stockpiled, will be going out of date.
What better way to get rid of it and regain their lost money than forecast a swine flu pandemic and force it on defenceless children?
MAUFACTURERS DATA FOR TAMIFLU
Oseltamivir phosphate (the anti-viral), pre-gelatinized starch (animal bones and starch), talc, povidone K-30, croscarmellose sodium, sodium stearyl fumarate, titanium dioxide, yellow iron oxide, black iron oxide, red iron oxide, blue ink colorant, sorbitol, monosodium citrate, xanthan gum, sodium benzoate, saccharin sodium, tutti-frutti flavor.
These ingredients listed are for the 12mgs, 30mgs and 45mgs capsules, which may vary slightly.
Resistance To Tamiflu
Influenza A virus isolates with reduced susceptibility to oseltamivir have been recovered by serial passage of virus in cell culture in the presence of increasing concentrations of oseltamivir is associated with mutations.
(i.e, influenza A can be resistant to Tamiflu and the more Tamiflu you have, the more resistance you get, like with antibiotics).
In clinical studies in the treatment of naturally aquired infection with influenza virus, 1.3% (1 out of 301)of post treatment isolates in adults and adolescents and 8.6% (9 out of 105) in pediatric patients aged 1 to 12 years showed emergence of influenza varients with decreased susceptibility in cell culture to oseltamivir.
(i.e, 1 out of every 301 adults and teenagers and 9 out of every 105 children up to the age of 12 were resistant to Tamiflu and got a new variant type of flu).
Risk of Renal Failure With Tamiflu
Administration of 100mgs twice daily of oseltamivir to patients with various degrees of renal impairment showed that exposure to oseltamivir is inversely proportional to declining renal function.
(i.e, people who have some degree of renal impairment suffered renal failure after taking Tamiflu).
Clinical Trial of Tamiflu
1355 patients were enrolled in the study. Of these, 849 had flu. The patients were aged 18-65 years old, with an average age of 34.
Those taking Tamiflu for 5 days in 75mgs doses, had a 1.3 day decrease in the amount of time they had flu, compared with the placebo (the data sheet didn't say what the placebo was).
For those taking 150mgs of Tamiflu for 5 days, there was no increased effectiveness when compared with the 75mgs dose.
Pediatric Trial of Tamiflu
698 patients aged between 1 and 12 years were enrolled in the trial and of those, 452 had flu. They were given 2mgs of Tamiflu, twice a day. They had a 1.5 day reduction of the length of their illness compared with the placebo (data sheet did not say what the placebo was).
* Any hypersensitivity to any of the ingredients
* Those with heart disorders and respiratory disorders should be cautious because the safety of the product has not been studied in these people.
* No information is available regarding treating influenza with Tamiflu in patients with any medical condition which is unstable or severe enough to require hospitalisation.
* The effectiveness of Tamiflu has not been studied in the immuno-compromised.
* The safety of Tamiflu in patients with hepatic impairment has not been evaluated.
* A lowered dose should be given to those with renal impairment.
* Patients less than 1 year old - the safety and efficacy of Tamiflu in patients less than 1 year because of uncertainities regarding the rate of development of the human blood/brain barrier.
I.E, THEY WON'T GIVE TAMIFLU TO INFANTS UNDER 1 BECAUSE THEY DON'T KNOW WHEN THE BLOOD/BRAIN BARRIER DEVELOPS! BUT WHAT ABOUT VACCINES?
THERE IS NO EVIDENCE OF EFFICACY OF TAMIFLU IN ANY ILLNESS CAUSED BY AGENTS OTHER THAN INFLUENZA A AND B VIRUSES - I.E. IT DOESN'T WORK FOR SWINE FLU!
SAFETY AND EFFICACY OF REPEATED TREATMENT WITH TAMIFLU HAS NOT BEEN STUDIED.
SERIOUS BACTERIAL INFECTIONS...MAY OCCUR AS COMPLICATIONS DURING THE COURSE OF INFLUENZA. TAMIFLU HAS NOT BEEN SHOWN TO PREVENT SUCH COMPLICATIONS.
SIDE-EFFECTS OF TAMIFLU
Rare cases of anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Steven-Johnsons Syndrome and erythema multiforme have been reported in post marketing experience with Tamiflu. Tamiflu should be stopped if an allergic like reaction occurs.
There have been post marketing reports of delirium and abnormal behaviour leading to injury and in some cases resulting in fatal outcomes.
Because these events were reported voluntarily during clinical practice, estimates of frequency cannot be made.
I.e, because reporting of adverse reactions is voluntary, they don't know how many people could suffer these reactions.
These events primarily happened in pediatric patients. The contribution of Tamiflu to these events has not yet been established.
If neuro-psychiatric symptoms occur, the risks and benefits of continuing treatment should be evaluated for each patient.
Nausea and vomiting were the most commonly reported side-effects.
There was an increase in nausea, vomiting, bronchitis, insomnia,and vertigo were more commonly reported in the Tamiflu group than the placebo group. Also more commonly reported in the Tamiflu group were aches and pains, rhinorrhea, dyspepsia, and upper respiratory tract infections.
Additional adverse events associated with Tamiflu that occured in less than 1% of patients were unstable angina, anemia, pseudomembranous colitis, humerus fracture, pneumonia, pyrexia, and peritonsillar abscess.
The most commonly reported adverse effects in pediatric patients aged 1 to 12 years, was vomiting, abdominal pain, epistaxis, ear disorder and conjunctivitis.
Side-effects observed during clinical practice are swelling of the face or tongue, allergy, anaphylactic reactions, dermatitis, rash, eczema, urticaria, erythemia multiforme, Steven-Johnsons Syndrome, Toxic Epidermal necrolysis, hepatitis, abnormal liver function tests, heart arrhythmias, gastrointestinal bleeding, hemorrhagic colitis, seizures, aggravation of diabetes, delirium, altered level of consciousness, confusion, abnormal behaviour, delusions, hallucinations, agitation, anxiety, nightmares.
In a 2 week study, a single dose of 1000mgs of oseltamivir to 7 day old unweaned rats, resulted in DEATHS.
However, in 14 day old unweaned rats, there were no deaths.
Source: August 2008 Roche Pharmaceuticals data sheet for Tamiflu:
JAPAN ISSUES TAMIFLU WARNING AFTER CHILD DEATHS - 2007 ARTICLE
The Japanese government has warned doctors that Tamiflu, the drug being stockpiled around the world as a defence against a bird flu pandemic, should not be prescribed to teenagers for fear that it can lead to bizarre and self-destructive behaviour.
Tokyo’s Ministry of Health and Welfare today instructed the Japanese distributor of the drug to include a warning not to give the drug to patients aged between 10 and 19, after reports that at least 18 Japanese children taking Tamiflu have died as a result of irrational behaviour.
Concern over Tamiflu will complicate international preparations for a catastrophic bird flu pandemic, against which it is seen as the final line of defence.
Despite scores of deaths in south-east Asia, there have been no cases of human bird flu in Japan, and the 8.6 million people who receive the drug every year are suffering from the common form of human influenza.
But for the past three years, there have been alarming stories of young people succumbing to fits of self-destructive behaviour while receiving Tamiflu.
Relatives who believe that their children were adversely affected by the drug have formed a lobby group to demand its withdrawal from sale.
One of the most disturbing cases was in February 2004 when a 17-year old boy took one capsule of Tamiflu at his home in Gifu prefecture, central Japan. No one was at home to witness what happened next, but he appears to have left the house in his pyjamas, walked barefoot through a snowstorm, climbed over two fences and stepped in front of an oncoming truck. The driver told police that he was smiling at the moment of impact.
At the end of last month, a fourteen year old boy in the city of Sendai told his mother that he was going to the toilet, but then walked out of the front door of his eleven storey apartment. His mother ran out to see him straddling the four foot guard rail and despite her cries of warning he fell to his death in the car park below. He had taken two Tamiflu capsules, the first day of a five day prescribed course for influenza.
According to Japan’s health ministry, most of the 54 Japanese who died after taking Tamiflu by October last year, succumbed to liver or other organ failure, most likely caused by influenza. But 16 of them were children aged 16 or under, several of whom had exhibited “abnormal” behaviour.
The drug is already sold in Japan with a general warning that users may have psychological side effects including abnormal behaviour and hallucinations.
Source: The Times, 21st March 2007.
DOCTOR SAYS TAMIFLU IS USELESS
After treating 41 victims of H5N1, the deadly form of the bird flu virus, a Vietnamese doctor has concluded Tamiflu, the drug most widely stockpiled around the world to combat a feared pandemic, is "useless."
Dr. Nguyen Tuong Van, who runs the intensive care unit of the Center for Tropical Diseases in Hanoi, followed World Health Organization guidelines in her treatment of patients but concluded it had no effect on the disease.
"We place no importance on using this drug on our patients," she said. "Tamiflu is really only meant for treating ordinary type A flu. It was not designed to combat H5N1 ... [Tamiflu] is useless."
Van said bird flu is far worse that SARS, an avian-linked respiratory illness, which she has also treated. Caring for H5N1 victims requires intensive patient "support" with modern technology, like ventilators and dialysis machines, if patients are to be kept alive. Even Western countries with wide access to technology would see there medical infrastructure strained to the limit if the dreaded pandemic comes.
Van did not criticize governments for stockpiling the drug but said doctors had to inform the public about its performance.
Roche, the Swiss pharmaceutical, has sold stockpiles of its Tamiflu to 40 countries and insists it's effective if administered within 48 hours of infection. Roche recently licensed Indonesia to manufacture Tamiflu for its own population.
The WHO confirms Van's experience, admitting Tamiflu has not been "widely successful in human patients," but speculates the drug has not been administered until late in the disease in many Asian countries.
Source: World Net Daily, 4th December 2005.
Tamiflu Linked To Suicides
TAMIFLU, one of the two drugs being used to combat swine flu, has been linked to suicidal behaviour in young people and has been ineffective at treating the current strain of human flu in the United States.
In Japan — the world's biggest user of Tamiflu, as the Japanese take it to treat regular influenza — the drug has been linked to eight deaths, including teenagers who have jumped from buildings and one who ran in front of a truck.
And resistance to Tamiflu among Americans with regular flu has leapt from 12 per cent last year to 98 per cent this year, leading to fears people with swine flu could also develop resistance.
According to Japan's health ministry, 128 people reported behaving abnormally after taking Tamiflu between 2004 and 2007 — 43 aged under 10, 57 aged 10 to 19, and 28 aged over 20. Five teens and three adults died in this period, most by jumping from buildings.
Of Tamiflu's estimated 50 million administered doses, about 60 per cent have been in Japan.
According to the Australian federal Department of Health, the Therapeutic Goods Administration has received two Australian reports of adverse psychiatric reactions to Tamiflu.
"These were reported in a 23-year-old who developed agitation, fever and headache after taking Tamiflu for an unspecified period of time, and depression and anxiety in a 39-year-old female," said spokeswoman Kay McNiece.
"There are no Australian reports of suicidal thoughts or behaviour. The (TGA) has received no reports of death associated with use of Tamiflu and no reports of adverse psychiatric (reactions) in children."
Ms McNiece said the Government's stockpile included Relenza in case anyone developed an adverse reaction to Tamiflu. She said the Government had stockpiled more Tamiflu than Relenza because it was taken in pill form, a delivery method preferred by patients, while Relenza must be inhaled via a Diskhaler device.
Tamiflu's safety information states: "People with the flu, particularly children and adolescents, may be at an increased risk of self-injury and confusion shortly after taking Tamiflu and should be closely monitored."
Source: theage.com.au, 31st May 2009.
Tamiflu is Giving Children Nightmares
More than half of children taking the swine flu drug Tamiflu experience side-effects such as nausea and nightmares, research suggests.
An estimated 150,000 people with flu symptoms were prescribed the drug through a new hotline and website last week, according to figures revealed yesterday.
Studies of children attending three schools in London and one in the South West showed that 51-53 per cent had one or more side-effects from the medication, which is offered to everyone in England with swine flu symptoms.
The research by the Health Protection Agency emerged as Sir Liam Donaldson, the Chief Medical Officer for England, said that swine flu infections “may have reached a plateau”.
Releasing the latest figures, Sir Liam said that an estimated 110,000 new cases of the H1N1 virus were diagnosed by doctors in the week to Sunday. That did not include those using the new National Pandemic Flu Service for England to obtain antiviral drugs without seeing their GP.
Sir Liam said that the deaths of 27 people in England were confirmed to have been linked to swine flu, compared with 26 last week. As of Wednesday morning 793 people were in hospital in England with the virus, and 81 were in intensive care.
Yesterday Natasha Newman, 16, of Highgate, North London, was seriously ill in hospital in Athens after contracting swine flu while on holiday on the island of Cephalonia. Her parents, Julian Newman and Nikki Boughton, were at her bedside at the Agia Sofia children’s hospital, said a spokeswoman for Mr Newman’s business, J. Newman Textiles. “This is a very distressing and worrying time,” she said.
Peter Holden, the British Medical Association’s lead expert on swine flu, suggested that Tamiflu was being overused and did not need to be offered to everyone with mild symptoms. “The National Pandemic Flu Service has been a great success, and was needed to take the pressure off GPs,” he said. “But the threshold for getting Tamiflu should be quite high.
“For patients who are not in the high-risk groups — such as pregnant women, people with bad asthma or with suppressed immune systems — this virus typically causes mild symptoms and does not require a course of Tamiflu. Patients in the at-risk groups should be referred to their GP, who will use their clinical judgment.”
A total of 103 children took part in the London study, of which 85 were given the drug as a precaution after a classmate received a diagnosis of swine flu. Of those, 45 experienced one or more side-effects. The most common was nausea (29 per cent), followed by stomach pain or cramps (20 per cent) and problems sleeping (12 per cent). Almost one in five had a “neuropsychiatric side-effect”, such as inability to think clearly, nightmares and “behaving strangely”, according to the research, published in Eurosurveillance, a journal of disease.
The study was carried out in April and May when the drug was being issued as a preventive measure. The findings were echoed by a study of children at a school in the South West where a pupil had caught the disease in Mexico.
Health officials in Japan have recommended against prescribing Tamiflu to teenagers over fears it causes a rise in “neuropsychiatric events”. The researchers said that clinical trials had shown that about 20 per cent of adults reported side-effects of either nausea or vomiting after taking Tamiflu.
Source: The Times, 31st July 2009.
Woman at Swine Flu Call Centre Blows the Whistle on Tamiflu
It’s ridiculous. In a five hour shift I answered the phone four times. Altogether there are about 400 of us in this newly organised centre - we’re all being paid £6 an hour, and we’re practically doing nothing. We sit around reading magazines, and every hour or so the phone rings and we get out the script. The lengthy disclaimer comes first, then it’s: “Do you need an ambulance?”, followed gradually by the tamer questions about coughs and headaches.
“But I kid you not, Will. I had a guy who rang up and said he’d been feeling ill, so had contacted the helpline in the morning and been prescribed Tamiflu. His Mum went to collect it. Meanwhile, he had a nap and afterwards felt much better, so he was ringing up to say he didn’t need the drug, and what should he do with it? Seriously! He had a peaky afternoon, so he ordered in the anti-virals.
“What terrifies me is that none of us in the centre has any medical training whatsoever. There’s a lot of bullshit in our handbook about us being specially selected, but actually I just filled in a form and was given the job the next day without an interview. Because of this, I’m obviously worried we’re giving out Tamiflu to people who don’t really need it. If there was a real Swine Flu pandemic, a lot of the people we speak to would be ****** – having already taken their dosage for a cold, they won’t be allowed it again. Another concern is that basically people convince themselves that Tamiflu is preventative…
“It strikes me that the government has set up this helpline as an insurance policy. But it’s wasting huge amounts of money. I’ve heard there are 1,500 of us all over the UK working almost non-stop. We’re giving out Tamiflu to people who are panicking because of what they’ve seen on the news, all basically so the NHS can say it’s doing its very best. I don’t blame pregnant women, the elderly, parents of young children – of course, they are genuinely terrified of a pandemic. But the other day a guy rang up complaining about a mild headache. I felt like saying, “hang up the phone, take a paracetemol, and get the hell back to work.”
Source: The Telegraph, 31 July 2009.
Teenager in Intensive Care With Burns and Unable to Breathe After Taking Tamiflu
A teenager is critically ill after taking the swine flu treatment Tamiflu prescribed by the Government's controversial helpline.
Samantha Millard, 18, was told she had the virus after describing her symptoms to staff with no medical training.
She took just three pills before developing blisters all over her body, and was today in intensive care unable to breathe on her own.
She is being treated at a specialist burns unit at Chelsea and Westminster Hospital where doctors fear she may have the life-threatening Stevens-Johnson syndrome which causes the skin to peel off.
The syndrome affects just three in a million people and is usually triggered by an adverse reaction to medication. The mortality rate is around 15 per cent.
Victims develop terrible scarring all over their bodies and well as severe conjunctivitis which can lead to blindness and mouth infections which can stop them eating.
Samantha's devastated mother Deborah, 41, told The Sun her family from Bicester in Oxfordshire were furious that Samantha had been wrongly given the treatment.
Sitting at Samantha's bedside with her other daughter Charley, 23, she said: 'It shouldn't be the case that people with no medical background can make these decisions.
'These people are just Joe Bloggs off the street. My daughter could die because of this. Her condition is getting worse.
Earlier this year the Daily Mail revealed some of the call centres speaking to people with suspected swine flu were manned by 16-year-olds with just three hours training.
A Roche spokeswoman said the incident would be investigated and could not rule out the role of Tamiflu in triggering the syndrome.
Source: The Daily Mail, 8 December 2009.
Teenager Blinded After Taking Tamiflu when She Didn't Even Have Swine Flu
A teenage girl left disabled by the swine flu treatment Tamiflu did not even have the virus, it was revealed today.
Samantha Millard, 19, became critically ill after suffering a severe allergic reaction to the tablets, which she took on the advice of the controversial NHS helpline.
Within 72 hours of taking three pills, doctors put her on life support.
Samantha spent a month in hospital after developing the life-threatening Stevens Johnson syndrome, which causes the skin to peel off, and later developed toxic epidermal necrolysis syndrome, which has damaged her sight.
But tests at the hospital have since revealed that she never even contracted the swine flu virus.
Her devastated mother Debbie Van Horenbeeck is now seeking legal advice about the information given out by the NHS swine flu helpline. She believes that Tamiflu has not been tested thoroughly enough.
‘They have disabled my daughter from that helpline,’ said the 42-year-old, who is now her daughter's full-time carer.
Read more: http://www.dailymail.co.uk/news/article-1244926/Girl-left-battling-blindness-taking-Tamiflu-did-swine-flu.html#ixzz0dKUpHUhS