We describe 3 cases of acute gastroenteritis in healthy infants after vaccination with RotaTeq, shedding a G1P human-bovine double reassortant rotavirus in stools. Such a double reassortant virus appears stable in vitro and may explain...Read more
Symptomatic Infection and Detection of Vaccine and Vaccine-Reassortant Rotavirus Strains in 5 Children: A Case Series
Vaccine or vaccine-reassortant rotavirus strains were detected in fecal specimens from 5 of 106 (4.7%) immunocompetent children who required treatment for rotavirus gastroenteritis at a large pediatric hospital in Texas in 2009–2010. Four strains...Read more
Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence...Read more
Transfer of antibody via mother’s milk
Abstract Differing from humans, IgG from breast milk in many animal species (rodents, bovines, cats, ferrets, etc.) are transported across the intestinal epithelium into the neonatal circulation. This transport is located at the duodenal and...Read more
Rotavirus antibodies in the mother and her breast-fed infant
Abstract The transfer of rotavirus antibodies from 25 healthy mothers to their breast-fed infants was investigated during the period of lactation (mean, 3.9 months; range, 1-9 months). Furthermore, the destiny of these antibodies in the...Read more
Local production of rotavirus specific IgA in breast tissue and transfer to neonates
Abstract Rotavirus specific IgA, secretory component, and IgG were measured by enzyme linked immunosorbent assay in 20 pairs of mothers and babies to estimate antibody transfer from the mother, particularly from breast milk to neonatal faeces...Read more
Cord blood and breast-milk antibodies in neonatal rotavirus infection
Studies were carried out during an outbreak of rotavirus type 2 infection in a neonatal nursery to determine the protective role of antibodies in cord blood and breast milk. The range, distribution, and geometric mean titres of rotavirus-specific...Read more
Human-Milk Glycans That Inhibit Pathogen Binding Protect Breast-feeding Infants against Infectious Diarrhea
Breast-feeding is a highly effective strategy for preventing morbidity and mortality in infancy. The human-milk glycans, which include oligosaccharides in their free and conjugated forms, constitute a major and an innate immunologic mechanism by...Read more
Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain.
Abstract Human Lactobacillus sp strain GG (Lactobacillus GG) administered during acute rotavirus diarrhea has been shown to promote clinical recovery. To elucidate the immune mechanisms behind such a favorable outcome, the ELISPOT (solid phase...Read more
Prevention of rotavirus-induced diarrhea by preferential secretion of IgA in breast milk via maternal administration of Lactobacillus gasseri SBT2055.
Abstract OBJECTIVES: Rotavirus (RV)-induced diarrhea poses a major health problem, particularly to infants. An effective measure to prevent RV infection is to consume breast milk with higher levels of protective IgA. We therefore examined whether...Read more
Breastfeeding Prevents Rotavirus!
The reason why this vaccine was developed (aside from money) is because children in third world countries without access to clean water and often the prey of baby milk companies who would stop mothers breastfeeding their infants, would develop...Read more
A GP Questions Costings
As an NHS GP I’m bound to be involved in this programme, although the actual vaccinations will be carried out by the practice nurses. I’m immediately suspicious of the published costings. See: http://www.advisorybodies.doh…. We...Read more