How Vaccines Affect Mental Health and Behaviour
Vaccines Induce an Inflammatory Response
Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling.
Early-life inflammation has been shown to exert profound effects on brain development and behavior, including altered emotional behavior, stress responsivity and neurochemical/neuropeptide receptor expression and function. The current study extends this research by examining the impact of inflammation, triggered with the bacterial compound lipopolysaccharide (LPS) on postnatal day (P) 14, on social behavior during adolescence. We investigated the role that the endocannabinoid (eCB) system plays in sociability after early-life LPS. To test this, multiple cohorts of Sprague Dawley rats were injected with LPS on P14. In adolescence, rats were subjected to behavioral testing in a reciprocal social interaction paradigm as well as the open field. We quantified eCB levels in the amygdala of P14 and adolescent animals (anandamide and 2-arachidonoylglycerol) as well as adolescent amygdaloid cannabinoid receptor 1 (CB1) binding site density and the hydrolytic activity of the enzyme fatty acid amide hydrolase (FAAH), which metabolizes the eCB anandamide. Additionally, we examined the impact of FAAH inhibition on alterations in social behavior. Our results indicate that P14 LPS decreases adolescent social behavior (play and social non-play) in males and females at P40. This behavioral alteration is accompanied by decreased CB1 binding, increased anandamide levels and increased FAAH activity. Oral administration of the FAAH inhibitor PF-04457845 (1mg/kg) prior to the social interaction task normalizes LPS-induced alterations in social behavior, while not affecting social behavior in the control group. Infusion of 10ng PF-04457845 into the basolateral amygdala normalized social behavior in LPS injected females. These data suggest that alterations in eCB signaling following postnatal inflammation contribute to impairments in social behavior during adolescence and that inhibition of FAAH could be a novel target for disorders involving social deficits such as social anxiety disorders or autism.
Source: Brain Behav Immun. 2016 Nov;58:237-247. doi: 10.1016/j.bbi.2016.07.152. Epub 2016 Jul 21.
Recurrence of Panic Attacks after Influenza Vaccination: Two Case Reports.
Human influenza is a contagious respiratory illness caused by the influenza virus. The influenza vaccination is recommended annually, but several adverse effects related to allergic reactions have been reported. Panic attacks are also known to occur, but no case of a panic attack adverse effect has been reported in South Korea. We present two cases of panic disorder patients whose symptoms were aggravated by the influenza vaccination. We assumed that dysregulation of T-lymphocytes in panic disorder patients could have a role in activating various kinds of cytokines and chemokines, which then can lead to panic attack aggravation.
Source: Clin Psychopharmacol Neurosci. 2016 Nov 30;14(4):396-398. doi: 10.9758/cpn.2016.14.4.396.
Effects of typhoid vaccine on inflammation and sleep in healthy participants: a double-blind, placebo-controlled, crossover study.
Neonatal Hepatitis B Vaccine in Mice Impaired Behaviour into Adulthood
Vaccines linked to mental disorders by Yale study
A recent Yale study has called into question the safety of vaccines and could lend fuel to anti-vaccine advocates like Robert F. Kennedy Jr., who has already written a piece covering the study on the news site EcoWatch.
The study, published last month in the journal Frontiers in Psychiatry, reports that patients diagnosed with neuropsychiatric disorders like obsessive-compulsive disorder and anorexia nervosa were more likely to have received vaccinations three months prior to their diagnoses. Though the collaboration between researchers at Pennsylvania State University and the Yale Child Study Center yielded results that seem to dispute the safety of vaccines, the authors asserted that the study needs replication on a larger scale and does not establish a causal relationship between vaccines and neuropsychiatric disorders.
“There’s a fair amount of interest in the vaccine safety question, so let’s try to be critical and do further studies that will help examine this issue in a more thorough way,” said James Leckman, professor of pediatrics and one of the study’s five authors.
Using information from a health insurance claims database, Leckman and his co-authors examined the correlations between specific vaccines and various neurological disorders in six- to 15-year-old children. Children with open wounds and broken bones were used as the two control groups.
While only about 10 percent of children with open wounds had received vaccinations, vaccines had been given to over 20 percent of children later diagnosed with anorexia. Higher numbers of vaccinated children were also found among those who were diagnosed with OCD, anxiety disorder and ADHD as soon as three months after their vaccinations.